Glucocorticosteroids in Relation to Inflammatory Disease
Summary :
Table of Contents
- Pharmacology
- Mechanisms of action
- Clinical use of glucocorticisteroids
- General principles of therapy
- Systemic Glucocorticosteroid therapy
- Alteration to oral therapy
- Conclusions
- Bibliography
Abstract
For more than 50 years, glucocorticosteroids have been important agents in treating diseases characterized by inflammation and exaggerated immune responses. The pioneering work of Hench and colleagues in rheumatoid arthritis showed the possible potency of these agents in such pathologic states.
Although substantial advances have been made in understanding the mechanisms by which glucocorticosteroids exert beneficial effects, considerable gaps in knowledge remain. Despite extensive data regarding the in vitro and in vivo activities of these drugs, it is probable that glucocorticosteroids have different beneficial activities in different diseases.
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