Neurotransmitter and Ion Channels
Summary :
Table of Contents
- Introduction
- Conductance mechanisms underlying neurotransmitter actions
- Structure of neurotransmitter receptors
- Conclusion
- References
Abstract
Classes of neurotransmitters Much of the information transfer between neurons in the CNS occurs via chemical synapses. These synapses use a variety of messengers (neurotransmitters) that are released in a Ca2+-dependent fashion from presynaptic terminals and act on specific protein receptors to produce biochemical and excitability changes in the receiving cell. There are two primary groups of neurotransmitters-low-molecular-weight amines and neuroactive peptides. These agents act on two classes of receptors, ligand-gated ion channels, at which the binding of the transmitter directly opens ion channels in the membrane, and G protein coupled receptors. The activated G protein then acts on ion channels or alters biochemical second-messenger systems. Physiologists classify synaptic transmission according to the speed of transmission (fast or slow) and according to the nature of the response (excitatory or inhibitory).
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Presentation | 11/28/2008 | en | .doc | 7 pages
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