The Effect of Benzodiazepine Drugs on the GABA(A) Receptor
Summary :
Table of Contents
- Introduction
- The GABA(A) receptor
- An accidental scientific discovery
- New benzodiazepines
- Positive effects of benzodiazepines
- Conclusion
- Works cited
Abstract
The gaba(A) receptor plays a vital role in the mammalian brain and is responsible for a large majority of inhibitory neurotransmissions in the central nervous system (Perrine 144). The gaba(A) receptor is a member of the ionotropic (ligand gated) family of receptors that uses gaba, otherwise known as γ-aminobutyric acid, as its ligand. The binding of gaba to the receptor opens the associated ion channel, which in this case is selectively permeable to chlorine ions as they pass down their electrochemical gradient. The negatively charged chlorine ions passing into the cell further negate the postsynaptic membrane potential, usually hyperpolarizing it. This makes it more difficult to depolarize the cell and decreases the probability of further propagation of action potential.
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